IGHV3OR16-17

Across TCGA patient cohorts, IGHV3OR16-17 mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3OR16-17-associated genes across cancer lineages are LINC02727, OR9H1P, and RNU6-165P. Each is linked with IGHV3OR16-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-17-to-partner and partner-to-IGHV3OR16-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02727 grouped by IGHV3OR16-17-low versus IGHV3OR16-17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-17→partner) and Y-score (partner→IGHV3OR16-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02727 →	+0.177	+2.863	.003	.009	3	2
SKCM	OR9H1P →	+0.107	+3.182	<.001	.006	3	2
LUAD	RNU6-165P →	+0.528	+7.930	<.001	.008	3	2
LUSC	DEFB117 →	+0.389	+5.081	<.001	.004	3	2
LUSC	MIR4650-2 →	+0.445	+5.309	<.001	.003	3	2
SKCM	LINC02742 →	+1.042	+4.254	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

LINC02727 by IGHV3OR16-17 expression — UCEC

Explore this box plot interactively →