IGHV3OR16-16

Across TCGA patient cohorts, IGHV3OR16-16 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,821 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3OR16-16-associated GO terms across cancer lineages are B cell mediated immunity, Antimicrobial humoral response, and Antibacterial humoral response. Each is linked with IGHV3OR16-16 in more than 24 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-16-to-partner and partner-to-IGHV3OR16-16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHV3OR16-16-low versus IGHV3OR16-16-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-16→partner) and Y-score (partner→IGHV3OR16-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.101	+0.572	<.001	<.001	3	25
THCA	Antimicrobial humoral response →	+0.113	+0.521	<.001	<.001	3	25
THCA	Antibacterial humoral response →	+0.172	+0.541	<.001	<.001	3	25
STAD	Immunoglobulin production →	+0.090	+0.615	<.001	<.001	3	25
ESCA	Positive regulation of lymphocyte differentiation →	+0.055	+0.327	<.001	.002	3	25
SKCM	B cell receptor signaling pathway →	+0.077	+0.353	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,821 associations by consensus.

B cell mediated immunity by IGHV3OR16-16 expression — THCA

Explore this box plot interactively →