IGHV3OR16-16

Across TCGA pan-cancer cohorts, IGHV3OR16-16 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3OR16-16’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3OR16-16 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3OR16-16 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and LUAD are the cancer types where IGHV3OR16-16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3OR16-16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.933	<.001	9	view →
READ	All	All	−0.945	.001	7	view →
LUAD	Female	All	+0.699	<.001	6	view →
BRCA	Female	II,III,IV	−0.194	.006	4	view →
KIRC	All	All	+0.142	.012	4	view →
ESCA	All	II,III,IV	+0.225	.023	2	view →
KICH	All	All	−0.165	.036	1	view →
HNSC	Female	III,IV	+0.094	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3OR16-16–COAD

Open the COAD breakdown →