IGHV3OR16-16

Across TCGA pan-cancer cohorts, IGHV3OR16-16 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-16 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-16 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and DLBC are the cancer types where IGHV3OR16-16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.835	0.613	<.001	127	view →
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
DLBC	DFS	Tertile	III,IV	0.074	0.984	.003	65	view →
SKCM	DFS	Median	III,IV	0.815	0.548	.007	45	view →
ACC	OS	Tertile	All	0.133	0.686	.004	45	view →
UCEC	OS	Quartile	III,IV	0.787	0.505	.010	42	view →
MESO	OS	Quartile	III,IV	0.758	0.489	.012	33	view →
LGG	OS	Tertile	All	0.319	0.813	.001	33	view →
ESCA	DFS	Tertile	II,III,IV	0.465	0.207	<.001	27	view →
LUAD	OS	Median	II,III,IV	0.713	0.484	.003	27	view →
KIRC	DFS	Quartile	III,IV	0.835	0.705	.013	13	view →
BRCA	OS	Tertile	All	0.669	0.556	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3OR16-16–HNSC (DFS)

Open the HNSC breakdown →