IGHV3-63

Across TCGA patient cohorts, IGHV3-63 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,095 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-63-associated GO terms across cancer lineages are Complement activation, Antimicrobial humoral response, and Antibacterial humoral response. Each is linked with IGHV3-63 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGHV3-63-to-partner and partner-to-IGHV3-63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation grouped by IGHV3-63-low versus IGHV3-63-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-63→partner) and Y-score (partner→IGHV3-63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Complement activation →	+0.152	+1.426	<.001	<.001	3	30
THCA	Antimicrobial humoral response →	+0.108	+1.489	<.001	<.001	3	30
THCA	Antibacterial humoral response →	+0.168	+1.546	<.001	<.001	3	30
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.163	+1.430	<.001	<.001	3	29
SKCM	B cell receptor signaling pathway →	+0.082	+1.227	<.001	<.001	3	29
CHOL	Regulation of B cell activation →	+0.058	+1.058	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,095 associations by consensus.

Complement activation by IGHV3-63 expression — THCA

Explore this box plot interactively →