IGHV3-63

Across TCGA pan-cancer cohorts, IGHV3-63 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3-63 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-63 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-63 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, STAD, and SKCM are the cancer types where IGHV3-63 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.673	0.533	<.001	144	view →
STAD	DFS	Tertile	All	0.566	0.782	<.001	62	view →
SKCM	DFS	Tertile	II,III,IV	0.835	0.608	.002	33	view →
BRCA	OS	Quartile	All	0.967	0.930	.010	32	view →
OV	DFS	Tertile	IV	0.609	0.264	.009	24	view →
SARC	OS	Tertile	All	0.947	0.810	.010	21	view →
ACC	DFS	Tertile	All	0.858	0.533	.018	21	view →
LUSC	DFS	Median	III,IV	0.443	0.190	.006	15	view →
DLBC	OS	Median	All	1.000	0.216	.003	13	view →
KIRP	DFS	Quartile	All	0.541	0.855	.010	13	view →
GBM	OS	Tertile	All	0.364	0.419	.014	12	view →
KICH	DFS	Tertile	II,III,IV	0.501	0.832	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGHV3-63–HNSC (DFS)

Open the HNSC breakdown →