IGHV3-63

Across TCGA pan-cancer cohorts, IGHV3-63 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3-63’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-63 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-63 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and READ are the cancer types where IGHV3-63 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-63 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.854	<.001	11	view →
LUAD	Female	All	+1.208	<.001	8	view →
READ	All	All	−2.413	<.001	5	view →
KIRC	Male	All	+0.570	<.001	4	view →
BRCA	Female	All	−0.516	<.001	4	view →
LIHC	Male	All	−0.417	.001	2	view →
ESCA	All	II,III,IV	+0.225	.023	2	view →
STAD	All	IV	−2.820	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3-63–COAD

Open the COAD breakdown →