IGHV3-6

Across TCGA patient cohorts, IGHV3-6 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,815 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-6-associated GO terms across cancer lineages are Regulation of B cell activation, B cell mediated immunity, and Antigen receptor-mediated signaling pathway. Each is linked with IGHV3-6 in more than 26 cancer types. Because this analysis shows association rather than direction, both IGHV3-6-to-partner and partner-to-IGHV3-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of B cell activation grouped by IGHV3-6-low versus IGHV3-6-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-6→partner) and Y-score (partner→IGHV3-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	Regulation of B cell activation →	+0.060	+0.666	<.001	.004	3	27
THCA	B cell mediated immunity →	+0.099	+0.699	<.001	<.001	3	27
SKCM	Antigen receptor-mediated signaling pathway →	+0.056	+0.464	<.001	<.001	3	26
THCA	Antibacterial humoral response →	+0.174	+0.662	<.001	<.001	3	26
STAD	Immunoglobulin production →	+0.077	+0.483	<.001	<.001	3	26
CHOL	B cell activation →	+0.052	+0.496	<.001	.004	2	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,815 associations by consensus.

Regulation of B cell activation by IGHV3-6 expression — CHOL

Explore this box plot interactively →