IGHV3-6

Across TCGA pan-cancer cohorts, IGHV3-6 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHV3-6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and COAD are the cancer types where IGHV3-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.734	0.586	<.001	144	view →
BRCA	OS	Median	All	0.665	0.514	<.001	86	view →
COAD	DFS	Tertile	All	0.811	0.627	<.001	79	view →
BLCA	DFS	Tertile	All	0.532	0.210	.007	62	view →
THYM	OS	Tertile	III,IV	0.229	1.000	<.001	50	view →
SKCM	DFS	Tertile	All	0.693	0.588	.002	50	view →
GBM	OS	Tertile	All	0.092	0.422	<.001	45	view →
KIRC	DFS	Tertile	All	0.742	0.914	<.001	36	view →
UVM	DFS	Tertile	All	0.275	0.783	.001	27	view →
MESO	OS	Quartile	III,IV	0.767	0.496	.014	26	view →
KIRP	DFS	Tertile	All	0.556	0.824	.014	24	view →
LGG	DFS	Tertile	All	0.507	0.827	.006	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHV3-6–HNSC (OS)

Open the HNSC breakdown →