IGHV3-6

Across TCGA pan-cancer cohorts, IGHV3-6 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3-6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-6 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-6 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3-6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.676	<.001	11	view →
LUAD	Female	All	+0.970	<.001	8	view →
KIRC	All	All	+0.189	.004	4	view →
BRCA	Female	All	−0.174	.010	4	view →
READ	Female	All	−1.110	<.001	2	view →
BLCA	Male	IV	+0.475	.032	1	view →
KICH	All	All	−0.178	.047	1	view →
LIHC	Female	All	+0.091	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3-6–COAD

Open the COAD breakdown →