IGHV3-57

Across TCGA patient cohorts, IGHV3-57 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,522 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV3-57-associated GO terms across cancer lineages are Immunoglobulin production, B cell receptor signaling pathway, and Antigen receptor-mediated signaling pathway. Each is linked with IGHV3-57 in more than 21 cancer types. Because this analysis shows association rather than direction, both IGHV3-57-to-partner and partner-to-IGHV3-57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin production grouped by IGHV3-57-low versus IGHV3-57-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-57→partner) and Y-score (partner→IGHV3-57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Immunoglobulin production →	+0.110	+0.074	<.001	<.001	3	22
ESCA	B cell receptor signaling pathway →	+0.106	+0.059	<.001	<.001	3	20
ESCA	Antigen receptor-mediated signaling pathway →	+0.087	+0.065	<.001	<.001	3	20
ESCA	B cell mediated immunity →	+0.128	+0.076	<.001	<.001	3	20
ESCA	Positive regulation of lymphocyte migration →	+0.087	+0.072	<.001	.001	3	19
LIHC	Regulation of B cell differentiation →	+0.100	+0.019	<.001	.002	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,522 associations by consensus.

Immunoglobulin production by IGHV3-57 expression — ESCA

Explore this box plot interactively →