IGHV3-57

Across TCGA pan-cancer cohorts, IGHV3-57 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated IGHV3-57 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-57 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-57 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, KICH, and COAD are the cancer types where IGHV3-57 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.595	0.313	.001	144	view →
KICH	DFS	Tertile	All	0.102	0.848	.004	39	view →
COAD	OS	Tertile	II,III,IV	0.735	0.863	.014	21	view →
READ	DFS	Tertile	IV	0.082	0.619	.001	18	view →
LUAD	OS	Quartile	III,IV	0.294	0.585	.004	16	view →
SKCM	DFS	Tertile	All	0.735	0.607	.027	12	view →
KIRC	DFS	Tertile	II,III,IV	0.918	0.771	.039	12	view →
STAD	OS	Tertile	II,III,IV	0.864	0.515	.044	9	view →
KIRP	OS	Tertile	All	0.463	0.706	.018	9	view →
THCA	DFS	Tertile	III,IV	0.787	0.931	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

IGHV3-57–HNSC (OS)

Open the HNSC breakdown →