IGHV3-57

Across TCGA pan-cancer cohorts, IGHV3-57 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHV3-57’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IGHV3-57 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-57 is over-expressed in tumor, although a few such as STAD and COAD show the opposite, repressed pattern.

STAD, COAD, and LUAD are the cancer types where IGHV3-57 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-57 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.217	.015	4	view →
COAD	All	All	−0.193	.004	4	view →
LUAD	All	All	+0.183	.001	4	view →
READ	All	All	−0.182	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHV3-57–STAD

Open the STAD breakdown →