IGHV3-52

Across TCGA patient cohorts, IGHV3-52 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,079 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-52-associated GO terms across cancer lineages are B cell receptor signaling pathway, B cell mediated immunity, and Antimicrobial humoral response. Each is linked with IGHV3-52 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGHV3-52-to-partner and partner-to-IGHV3-52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV3-52-low versus IGHV3-52-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-52→partner) and Y-score (partner→IGHV3-52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.087	+0.997	<.001	<.001	3	29
LAML	B cell mediated immunity →	+0.107	+1.461	<.001	<.001	3	29
THCA	Antimicrobial humoral response →	+0.104	+1.375	<.001	<.001	3	29
CHOL	CD4-positive, alpha-beta T cell activation →	+0.061	+1.689	<.001	<.001	3	29
ESCA	Regulation of B cell activation →	+0.068	+1.099	<.001	<.001	3	28
ESCA	Positive regulation of respiratory burst →	+0.142	+0.973	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,079 associations by consensus.

B cell receptor signaling pathway by IGHV3-52 expression — CHOL

Explore this box plot interactively →