IGHV3-52

Across TCGA pan-cancer cohorts, IGHV3-52 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3-52’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-52 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-52 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV3-52 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-52 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.744	<.001	10	view →
LUAD	Male	III,IV	+2.036	<.001	9	view →
BRCA	Female	II,III,IV	−0.585	<.001	6	view →
KICH	Male	III,IV	−0.310	.006	6	view →
LIHC	Male	III,IV	−0.431	.001	4	view →
READ	All	All	−2.212	<.001	3	view →
KIRC	All	All	+0.412	.003	2	view →
LUSC	All	All	+0.533	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3-52–COAD

Open the COAD breakdown →