IGHV3-52

Across TCGA pan-cancer cohorts, IGHV3-52 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3-52 data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IGHV3-52 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-52 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

ACC, HNSC, and COAD are the cancer types where IGHV3-52 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.509	0.896	<.001	147	view →
HNSC	DFS	Median	All	0.755	0.635	<.001	144	view →
COAD	DFS	Tertile	All	0.677	0.444	<.001	68	view →
BRCA	OS	Quartile	All	0.981	0.936	<.001	60	view →
SKCM	DFS	Quartile	All	0.907	0.689	<.001	60	view →
UCEC	DFS	Median	III,IV	0.669	0.460	.015	34	view →
PAAD	DFS	Median	II,III,IV	0.383	0.213	.004	30	view →
STAD	OS	Median	All	0.592	0.732	.006	30	view →
UVM	DFS	Tertile	All	0.533	0.765	.028	27	view →
LGG	OS	Tertile	All	0.531	0.902	<.001	24	view →
LUAD	DFS	Quartile	II,III,IV	0.838	0.416	.001	21	view →
CHOL	DFS	Quartile	All	0.805	0.289	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3-52–ACC (OS)

Open the ACC breakdown →