IGHV3-52

Across TCGA patient cohorts, IGHV3-52 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-52-associated genes across cancer lineages are RNU6-509P, RNU4-85P, and RNU6-484P. Each is linked with IGHV3-52 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-52-to-partner and partner-to-IGHV3-52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-509P grouped by IGHV3-52-low versus IGHV3-52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-52→partner) and Y-score (partner→IGHV3-52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-509P →	+0.741	+4.073	<.001	.004	3	1
UCEC	RNU4-85P →	+0.607	+4.262	<.001	.003	3	1
UCEC	RNU6-484P →	+0.720	+4.166	.003	.004	3	1
UCEC	RNU6-933P →	+0.935	+4.184	<.001	.004	3	1
UCEC	MIR199A1 →	+0.931	+4.061	.001	.005	3	1
UCEC	IGLJ7 →	+1.575	+3.831	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

RNU6-509P by IGHV3-52 expression — UCEC

Explore this box plot interactively →