IGHV3-47

Across TCGA patient cohorts, IGHV3-47 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,122 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-47-associated GO terms across cancer lineages are B cell receptor signaling pathway, CD4-positive, alpha-beta T cell activation, and B cell activation. Each is linked with IGHV3-47 in more than 30 cancer types. Because this analysis shows association rather than direction, both IGHV3-47-to-partner and partner-to-IGHV3-47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHV3-47-low versus IGHV3-47-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-47→partner) and Y-score (partner→IGHV3-47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.079	+1.001	<.001	<.001	3	31
ESCA	CD4-positive, alpha-beta T cell activation →	+0.044	+0.640	<.001	<.001	3	30
CHOL	B cell activation →	+0.052	+0.998	<.001	<.001	3	30
ESCA	CD4-positive, alpha-beta T cell differentiation →	+0.068	+1.005	<.001	<.001	3	30
CHOL	Regulation of lymphocyte differentiation →	+0.055	+1.829	<.001	<.001	3	30
CHOL	Positive regulation of respiratory burst →	+0.163	+1.226	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,122 associations by consensus.

B cell receptor signaling pathway by IGHV3-47 expression — CHOL

Explore this box plot interactively →