IGHV3-47

Across TCGA pan-cancer cohorts, IGHV3-47 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGHV3-47 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-47 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-47 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where IGHV3-47 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.666	0.540	<.001	144	view →
UCEC	DFS	Median	II,III,IV	0.726	0.259	<.001	80	view →
SKCM	OS	Tertile	All	0.433	0.252	<.001	72	view →
BRCA	DFS	Tertile	All	0.531	0.448	.001	56	view →
KIRP	OS	Quartile	All	0.331	0.774	<.001	37	view →
KIRC	DFS	Tertile	All	0.649	0.848	.003	30	view →
GBM	DFS	Tertile	All	0.076	0.306	<.001	27	view →
UVM	OS	Tertile	II,III,IV	0.325	0.661	.017	24	view →
LUAD	OS	Tertile	II,III,IV	0.764	0.499	.004	24	view →
LGG	OS	Tertile	All	0.694	0.901	<.001	21	view →
PAAD	OS	Tertile	II,III,IV	0.666	0.436	.007	16	view →
MESO	OS	Median	All	0.698	0.320	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGHV3-47–HNSC (DFS)

Open the HNSC breakdown →