IGHV3-47

Across TCGA pan-cancer cohorts, IGHV3-47 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3-47’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-47 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-47 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3-47 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-47 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.436	<.001	10	view →
LUAD	Female	All	+1.193	<.001	8	view →
KIRC	Male	All	+0.591	<.001	6	view →
READ	All	All	−2.075	<.001	5	view →
BRCA	Female	II,III,IV	−0.485	.001	4	view →
CHOL	All	II,III,IV	−0.840	.013	2	view →
STAD	All	IV	−3.526	.047	1	view →
LIHC	Male	All	−0.257	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3-47–COAD

Open the COAD breakdown →