IGHV3-42

Across TCGA patient cohorts, IGHV3-42 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,975 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-42-associated GO terms across cancer lineages are B cell activation, Immunoglobulin production, and Antigen receptor-mediated signaling pathway. Each is linked with IGHV3-42 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGHV3-42-to-partner and partner-to-IGHV3-42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell activation grouped by IGHV3-42-low versus IGHV3-42-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-42→partner) and Y-score (partner→IGHV3-42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell activation →	+0.067	+1.244	<.001	<.001	3	28
STAD	Immunoglobulin production →	+0.087	+0.744	<.001	<.001	3	28
CHOL	Antigen receptor-mediated signaling pathway →	+0.079	+0.978	<.001	<.001	3	28
CHOL	B cell receptor signaling pathway →	+0.103	+1.054	<.001	.002	3	28
STAD	Regulation of B cell activation →	+0.057	+0.449	<.001	<.001	3	28
THCA	B cell mediated immunity →	+0.098	+0.837	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,975 associations by consensus.

B cell activation by IGHV3-42 expression — CHOL

Explore this box plot interactively →