IGHV3-42

Across TCGA pan-cancer cohorts, IGHV3-42 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3-42 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-42 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-42 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and UCEC are the cancer types where IGHV3-42 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.720	0.602	<.001	144	view →
KIRC	DFS	Tertile	III,IV	0.761	0.578	<.001	99	view →
UCEC	DFS	Median	III,IV	0.792	0.416	<.001	82	view →
BRCA	DFS	Median	All	0.601	0.461	<.001	79	view →
SKCM	OS	Tertile	All	0.487	0.277	<.001	57	view →
GBM	OS	Tertile	All	0.142	0.420	<.001	54	view →
MESO	OS	Median	III,IV	0.696	0.479	.008	46	view →
KIRP	DFS	Tertile	All	0.572	0.840	.004	41	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	36	view →
LGG	DFS	Tertile	All	0.313	0.743	<.001	33	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
LIHC	DFS	Tertile	II,III,IV	0.509	0.258	.021	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGHV3-42–HNSC (OS)

Open the HNSC breakdown →