IGHV3-42

Across TCGA pan-cancer cohorts, IGHV3-42 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV3-42’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV3-42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV3-42 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

LUAD, COAD, and BRCA are the cancer types where IGHV3-42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+1.108	<.001	9	view →
COAD	All	All	−0.981	<.001	8	view →
BRCA	Female	All	−0.225	.010	6	view →
KIRC	All	All	+0.273	<.001	4	view →
STAD	Male	IV	−2.679	.001	3	view →
READ	All	All	−1.447	.002	3	view →
HNSC	All	III,IV	+0.379	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV3-42–LUAD

Open the LUAD breakdown →