Across TCGA pan-cancer cohorts, IGHV3-38 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGHV3-38 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-38 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3-38 expression acts as an unfavorable survival marker.

HNSC, LUAD, and UCEC are the cancer types where IGHV3-38 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.128	0.710	.001	36	view →
LUAD	OS	Median	II,III,IV	0.068	0.709	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGHV3-38 tumor-vs-normal RNA expression · all IGHV3-38 data types