Across TCGA pan-cancer cohorts, IGHV3-38 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGHV3-38 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGHV3-38 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-38 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where IGHV3-38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	1.000	0.554	.007	20	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.331	.009	9	view →
UCEC	OS	Tertile	All	0.904	1.000	.026	6	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	5	view →
GBM	DFS	Quartile	All	0.540	0.213	.028	4	view →
PDAC	OS	Tertile	III,IV	0.506	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: IGHV3-38 tumor-vs-normal RNA expression · all IGHV3-38 data types