Across TCGA patient cohorts, IGHV3-35 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,859 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV3-35-associated proteins across cancer lineages are MZB1, PLCG2, and CD38. Each is linked with IGHV3-35 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHV3-35-to-partner and partner-to-IGHV3-35 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-35→partner) and Y-score (partner→IGHV3-35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MZB1 →	+1.016	+1.285	<.001	<.001	3	8
LSCC	PLCG2 →	+0.700	+1.188	<.001	<.001	3	7
LSCC	CD38 →	+1.007	+1.275	<.001	<.001	3	7
GBM	CD48 →	+0.779	+0.184	<.001	.009	3	7
LSCC	IRF4 →	+1.057	+1.285	<.001	<.001	3	7
UCEC	MYO1G →	+0.548	+1.400	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,859 associations by consensus.

Exploration

IGHV3-35 survival (RNA) · tumor vs normal (RNA) · all IGHV3-35 data types