Across TCGA patient cohorts, IGHV3-35 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-35-associated genes across cancer lineages are RPS15AP32, RNU6-709P, and GHSR. Each is linked with IGHV3-35 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-35-to-partner and partner-to-IGHV3-35 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-35→partner) and Y-score (partner→IGHV3-35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS15AP32 →	+0.483	+6.392	<.001	.001	3	2
COAD	RNU6-709P →	+1.053	+7.142	<.001	<.001	3	2
SKCM	GHSR →	+0.074	+4.563	<.001	.004	3	1
SKCM	CRH →	+0.318	+4.661	<.001	.004	3	1
UCEC	MIR8082 →	+0.700	+4.146	<.001	.003	3	1
SKCM	WBP1LP10 →	+0.139	+7.228	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

IGHV3-35 survival (RNA) · tumor vs normal (RNA) · all IGHV3-35 data types