IGHV3-32

Across TCGA patient cohorts, IGHV3-32 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,634 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHV3-32-associated GO terms across cancer lineages are B cell mediated immunity, Thymic T cell selection, and Immunoglobulin production. Each is linked with IGHV3-32 in more than 22 cancer types. Because this analysis shows association rather than direction, both IGHV3-32-to-partner and partner-to-IGHV3-32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHV3-32-low versus IGHV3-32-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-32→partner) and Y-score (partner→IGHV3-32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.111	+0.112	<.001	<.001	3	23
THYM	Thymic T cell selection →	+0.113	+1.267	<.001	<.001	3	21
THCA	Immunoglobulin production →	+0.082	+0.115	<.001	<.001	3	21
STAD	Leukocyte apoptotic process →	+0.071	+0.273	<.001	<.001	3	21
STAD	B cell activation →	+0.065	+0.184	<.001	<.001	3	20
THCA	Positive T cell selection →	+0.075	+0.101	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,634 associations by consensus.

B cell mediated immunity by IGHV3-32 expression — THCA

Explore this box plot interactively →