IGHV3-32

Across TCGA pan-cancer cohorts, IGHV3-32 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGHV3-32 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGHV3-32 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-32 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

UVM, KICH, and UCEC are the cancer types where IGHV3-32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.189	0.728	.002	72	view →
KICH	DFS	Tertile	All	0.324	0.872	<.001	69	view →
UCEC	OS	Tertile	IV	0.242	0.623	.017	36	view →
KIRC	DFS	Tertile	IV	0.768	0.456	.025	30	view →
KIRP	DFS	Tertile	All	0.541	0.806	.010	27	view →
LUSC	DFS	Tertile	III,IV	0.184	0.682	.026	21	view →
LIHC	DFS	Tertile	II,III,IV	0.214	0.346	.024	21	view →
SKCM	DFS	Tertile	All	0.692	0.582	.012	19	view →
GBM	OS	Tertile	All	0.164	0.418	.028	18	view →
LUAD	DFS	Tertile	IV	0.240	0.625	.030	18	view →
UCS	OS	Tertile	All	0.153	0.687	.019	18	view →
COAD	OS	Tertile	IV	0.807	0.388	.033	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGHV3-32–UVM (OS)

Open the UVM breakdown →