IGHV3-32

Across TCGA pan-cancer cohorts, IGHV3-32 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHV3-32’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-32 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-32 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and LUSC are the cancer types where IGHV3-32 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-32 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.260	<.001	7	view →
READ	Male	All	−0.339	<.001	6	view →
LUSC	Male	All	+0.190	.004	2	view →
LUAD	All	All	+0.184	.001	2	view →
STAD	Male	III,IV	−0.343	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGHV3-32–COAD

Open the COAD breakdown →