IGHV3-30

Across TCGA pan-cancer cohorts, IGHV3-30 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHV3-30 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGHV3-30 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-30 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where IGHV3-30 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.214	.006	14	view →
CCRCC	DFS	Median	All	1.000	0.536	.003	13	view →
LUAD	OS	Median	III,IV	0.269	0.808	.004	12	view →
PDAC	DFS	Tertile	III,IV	0.339	0.915	.026	3	view →
GBM	OS	Median	All	0.359	0.628	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGHV3-30–LSCC (DFS)

Open the LSCC breakdown →