IGHV3-30

Across TCGA pan-cancer cohorts, IGHV3-30 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHV3-30’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGHV3-30 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGHV3-30 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where IGHV3-30 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-30 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.657	<.001	6	view →
LUAD	All	All	−0.290	.038	1	view →
CCRCC	All	All	+0.190	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGHV3-30–HNSC

Open the HNSC breakdown →