IGHV3-29

Across TCGA patient cohorts, IGHV3-29 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,492 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV3-29-associated proteins across cancer lineages are PTPN7_S149, SEPTIN1, and IKZF1_S445. Each is linked with IGHV3-29 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHV3-29-to-partner and partner-to-IGHV3-29 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3-29 versus PTPN7_S149 in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-29→partner) and Y-score (partner→IGHV3-29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTPN7_S149 →	+0.591	+0.447	<.001	<.001	3	4
LSCC	SEPTIN1 →	+0.566	+0.417	<.001	<.001	3	4
LUAD	IKZF1_S445 →	+1.157	+0.614	<.001	.003	3	4
LSCC	DAB2 →	+0.363	+0.304	<.001	<.001	3	3
LSCC	IRF4 →	+0.818	+0.555	<.001	<.001	3	3
LSCC	STK17B →	+0.285	+0.370	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,492 associations by consensus.

IGHV3-29 vs PTPN7_S149 — LSCC

Explore this scatter interactively →