IGHV3-29

Across TCGA pan-cancer cohorts, IGHV3-29 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHV3-29’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV3-29 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV3-29 is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

LUAD, READ, and LUSC are the cancer types where IGHV3-29 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-29 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.413	<.001	4	view →
READ	All	III,IV	−1.390	.014	3	view →
LUSC	Male	All	+0.240	.025	1	view →
KIRC	All	All	+0.056	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHV3-29–LUAD

Open the LUAD breakdown →