IGHV3-29

Across TCGA pan-cancer cohorts, IGHV3-29 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGHV3-29 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-29 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-29 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and ESCA are the cancer types where IGHV3-29 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.727	0.311	.001	89	view →
BLCA	OS	Tertile	All	0.895	0.602	<.001	81	view →
ESCA	DFS	Quartile	III,IV	0.689	0.335	.003	72	view →
OV	OS	Tertile	III,IV	0.447	0.301	.014	30	view →
LAML	DFS	Quartile	All	0.381	0.615	.001	24	view →
KIRC	DFS	Tertile	All	0.658	0.836	.002	18	view →
LUAD	OS	Quartile	II,III,IV	0.614	0.357	.008	14	view →
SKCM	DFS	Quartile	All	0.349	0.173	.009	11	view →
GBM	DFS	Tertile	All	0.072	0.246	.010	9	view →
STAD	DFS	Median	All	0.457	0.597	.017	9	view →
LUSC	DFS	Median	IV	0.827	0.134	.024	5	view →
THYM	DFS	Quartile	III,IV	0.501	1.000	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGHV3-29–HNSC (OS)

Open the HNSC breakdown →