IGHV3-19

Across TCGA patient cohorts, IGHV3-19 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,124 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-19-associated GO terms across cancer lineages are B cell mediated immunity, Antigen receptor-mediated signaling pathway, and B cell receptor signaling pathway. Each is linked with IGHV3-19 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGHV3-19-to-partner and partner-to-IGHV3-19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHV3-19-low versus IGHV3-19-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-19→partner) and Y-score (partner→IGHV3-19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	B cell mediated immunity →	+0.101	+1.627	<.001	<.001	3	28
LAML	Antigen receptor-mediated signaling pathway →	+0.068	+1.234	<.001	<.001	3	27
CHOL	B cell receptor signaling pathway →	+0.091	+1.256	<.001	<.001	3	27
CHOL	Regulation of B cell activation →	+0.054	+1.096	<.001	<.001	3	27
SKCM	Lymphocyte activation involved in immune response →	+0.041	+1.083	<.001	<.001	3	27
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.160	+1.576	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,124 associations by consensus.

B cell mediated immunity by IGHV3-19 expression — LAML

Explore this box plot interactively →