IGHV3-19

Across TCGA pan-cancer cohorts, IGHV3-19 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV3-19 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-19 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-19 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGHV3-19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.762	0.617	<.001	143	view →
BRCA	OS	Median	All	0.976	0.948	<.001	94	view →
SKCM	OS	Median	II,III,IV	0.921	0.752	<.001	93	view →
UCEC	OS	Tertile	III,IV	0.745	0.442	.002	40	view →
PAAD	DFS	Median	II,III,IV	0.379	0.206	.002	31	view →
LUAD	OS	Tertile	III,IV	0.717	0.335	.001	31	view →
MESO	OS	Median	All	0.710	0.310	.007	24	view →
DLBC	DFS	Median	All	0.606	1.000	.011	24	view →
LGG	DFS	Tertile	All	0.602	0.381	.003	23	view →
CHOL	DFS	Quartile	All	0.811	0.242	.003	21	view →
COAD	DFS	Median	All	0.782	0.614	.006	18	view →
PCPG	OS	Median	All	0.911	1.000	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV3-19–HNSC (DFS)

Open the HNSC breakdown →