IGHV3-19

Across TCGA pan-cancer cohorts, IGHV3-19 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGHV3-19’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-19 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-19 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV3-19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.043	<.001	10	view →
LUAD	Female	All	+1.426	<.001	10	view →
BRCA	Female	II,III,IV	−0.565	.001	4	view →
KIRC	All	All	+0.532	<.001	4	view →
READ	All	All	−2.457	<.001	3	view →
STAD	Male	IV	−4.595	.005	2	view →
LIHC	Male	All	−0.360	.014	2	view →
HNSC	All	III,IV	+0.743	.038	1	view →
LUSC	All	All	+0.630	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGHV3-19–COAD

Open the COAD breakdown →