IGHV2-70

Across TCGA patient cohorts, IGHV2-70 protein abundance is significantly associated with the RNA expression of many other genes, with 7,038 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IGHV2-70-associated genes across cancer lineages are MEI1, BRI3BP, and IL16. Each is linked with IGHV2-70 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHV2-70-to-partner and partner-to-IGHV2-70 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV2-70 versus MEI1 in LSCC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-70→partner) and Y-score (partner→IGHV2-70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEI1 →	+0.747	+0.659	<.001	.001	3	3
LSCC	BRI3BP →	-0.491	-0.513	<.001	.002	3	3
GBM	IL16 →	+0.725	+1.261	<.001	<.001	3	3
LSCC	PLEKHJ1 →	-0.444	-0.708	<.001	.003	3	3
GBM	IGHV1-69D →	+1.377	+1.168	.001	<.001	3	3
PDAC	KPNA5 →	+0.446	+1.068	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,038 associations by consensus.

IGHV2-70 vs MEI1 — LSCC

Explore this scatter interactively →