IGHV2-70

Across TCGA pan-cancer cohorts, IGHV2-70 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV2-70’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV2-70 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV2-70 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and BLCA are the cancer types where IGHV2-70 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV2-70 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.534	<.001	10	view →
LUAD	Female	All	+2.097	<.001	7	view →
BLCA	Male	IV	+2.632	.033	4	view →
LIHC	Male	All	−1.241	<.001	4	view →
KIRC	All	All	+1.187	<.001	4	view →
BRCA	Female	II,III,IV	−0.739	.015	4	view →
CHOL	All	II,III,IV	−1.724	.045	2	view →
HNSC	All	III,IV	+1.576	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV2-70–COAD

Open the COAD breakdown →