IGHV2-70

Across TCGA pan-cancer cohorts, IGHV2-70 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV2-70 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV2-70 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV2-70 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LIHC are the cancer types where IGHV2-70 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.809	0.635	<.001	135	view →
SKCM	OS	Median	All	0.867	0.678	<.001	65	view →
LIHC	DFS	Tertile	III,IV	0.645	0.200	.001	33	view →
LUAD	OS	Quartile	II,III,IV	0.778	0.464	.004	25	view →
UCEC	DFS	Tertile	III,IV	0.678	0.419	.025	22	view →
SARC	OS	Median	All	0.812	0.680	.003	17	view →
GBM	OS	Median	All	0.216	0.301	.033	15	view →
BRCA	OS	Quartile	II,III,IV	0.702	0.538	.016	11	view →
UCS	OS	Tertile	II,III,IV	0.770	0.373	.018	8	view →
DLBC	OS	Tertile	II,III,IV	0.956	0.628	.039	8	view →
COAD	OS	Median	II,III,IV	0.624	0.496	.017	7	view →
LUSC	DFS	Median	III,IV	0.427	0.194	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV2-70–HNSC (DFS)

Open the HNSC breakdown →