IGHV2-70

Across TCGA patient cohorts, IGHV2-70 mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV2-70-associated genes across cancer lineages are OLFM1, CPTP, and LONRF2P4. Each is linked with IGHV2-70 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV2-70-to-partner and partner-to-IGHV2-70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OLFM1 grouped by IGHV2-70-low versus IGHV2-70-high in DLBC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-70→partner) and Y-score (partner→IGHV2-70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	OLFM1 →	-0.837	-3.169	.008	.005	3	1
DLBC	CPTP →	-0.483	-3.076	.001	.005	3	1
DLBC	LONRF2P4 →	+0.049	+2.652	<.001	.007	3	1
DLBC	MIR4672 →	+0.448	+2.485	<.001	.005	3	1
DLBC	MIR4505 →	+0.630	+2.857	.003	.001	3	1
UCEC	RNU6-336P →	+0.485	+4.852	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

OLFM1 by IGHV2-70 expression — DLBC

Explore this box plot interactively →