IGHV2-70

Across TCGA patient cohorts, IGHV2-70 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. DLBC shows the largest number of these associations.

The most reproducible IGHV2-70-associated genes across cancer lineages are Pericytes, Eosinophils, and Neurons. Each is linked with IGHV2-70 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV2-70-to-partner and partner-to-IGHV2-70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pericytes grouped by IGHV2-70-low versus IGHV2-70-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2-70→partner) and Y-score (partner→IGHV2-70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Pericytes →	+0.058	+3.339	.002	.038	3	1
SKCM	Eosinophils →	+0.041	+1.930	.022	.040	3	1
SKCM	Neurons →	+0.017	+1.893	.048	.031	3	1
DLBC	Hepatocytes →	+0.017	+2.061	.029	.036	3	1
DLBC	Th2 cells →	+0.273	+2.061	.011	.036	3	1
DLBC	Skeletal muscle →	+0.038	+3.231	.010	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Pericytes by IGHV2-70 expression — LUAD

Explore this box plot interactively →