IGHV1OR21-1

Across TCGA patient cohorts, IGHV1OR21-1 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,849 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV1OR21-1-associated proteins across cancer lineages are IRF4, MZB1, and ADA2. Each is linked with IGHV1OR21-1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHV1OR21-1-to-partner and partner-to-IGHV1OR21-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV1OR21-1 versus IRF4 in LSCC, with a Pearson correlation of 0.74.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1OR21-1→partner) and Y-score (partner→IGHV1OR21-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF4 →	+0.989	+1.323	<.001	<.001	3	8
UCEC	MZB1 →	+1.163	+0.341	<.001	<.001	3	8
LSCC	ADA2 →	+0.504	+0.756	<.001	<.001	3	6
LSCC	CD38 →	+0.958	+1.322	<.001	<.001	3	6
LSCC	SEC11C →	+1.151	+1.307	<.001	<.001	3	6
LSCC	SEPTIN1 →	+0.696	+0.776	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,849 associations by consensus.

IGHV1OR21-1 vs IRF4 — LSCC

Explore this scatter interactively →