IGHV1OR21-1

Across TCGA pan-cancer cohorts, IGHV1OR21-1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV1OR21-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1OR21-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1OR21-1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV1OR21-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1OR21-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.234	<.001	9	view →
LUAD	Male	All	+1.450	<.001	7	view →
KIRC	Male	All	+0.488	<.001	4	view →
READ	All	All	−1.466	.002	3	view →
CHOL	All	II,III,IV	−0.635	.036	2	view →
STAD	All	IV	−3.313	.023	1	view →
LUSC	All	All	+0.676	.016	1	view →
LIHC	Male	All	−0.277	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV1OR21-1–COAD

Open the COAD breakdown →