IGHV1OR21-1

Across TCGA pan-cancer cohorts, IGHV1OR21-1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHV1OR21-1 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR21-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1OR21-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGHV1OR21-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.788	0.631	<.001	144	view →
SKCM	OS	Median	All	0.403	0.281	.001	78	view →
UCEC	OS	Tertile	III,IV	0.778	0.490	.002	40	view →
GBM	OS	Tertile	All	0.260	0.426	.008	36	view →
KIRP	OS	Quartile	All	0.476	0.780	.003	31	view →
COAD	OS	Median	II,III,IV	0.651	0.539	.022	30	view →
CESC	DFS	Quartile	All	0.806	0.648	.016	24	view →
PAAD	OS	Quartile	II,III,IV	0.657	0.380	.002	19	view →
BRCA	OS	Median	All	0.974	0.950	.004	18	view →
BLCA	DFS	Quartile	All	0.740	0.541	.037	12	view →
LUAD	DFS	Quartile	II,III,IV	0.772	0.520	.019	12	view →
TGCT	DFS	Quartile	All	0.950	0.707	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHV1OR21-1–HNSC (DFS)

Open the HNSC breakdown →