IGHV1OR21-1

Across TCGA patient cohorts, IGHV1OR21-1 protein abundance is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV1OR21-1-associated genes across cancer lineages are DYNLRB1, COX6A2, and CD151. Each is linked with IGHV1OR21-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1OR21-1-to-partner and partner-to-IGHV1OR21-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV1OR21-1 versus DYNLRB1 in LSCC, with a Pearson correlation of -0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1OR21-1→partner) and Y-score (partner→IGHV1OR21-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DYNLRB1 →	-0.338	-1.394	.009	.008	2	1
LSCC	COX6A2 →	-0.330	-1.394	.004	.008	2	1
LSCC	CD151 →	-0.740	-1.394	.004	.008	2	1
LSCC	RN7SKP44 →	-0.466	-1.394	.004	.008	2	1
LSCC	SNORA14B →	-0.910	-1.394	<.001	.008	2	1
LSCC	SNORA49 →	-1.876	-1.394	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

IGHV1OR21-1 vs DYNLRB1 — LSCC

Explore this scatter interactively →