IGHV1OR21-1

Across TCGA patient cohorts, IGHV1OR21-1 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. SARC shows the largest number of these associations.

The most reproducible IGHV1OR21-1-associated genes across cancer lineages are OR8G1, OR56A1, and RN7SKP36. Each is linked with IGHV1OR21-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1OR21-1-to-partner and partner-to-IGHV1OR21-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8G1 grouped by IGHV1OR21-1-low versus IGHV1OR21-1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1OR21-1→partner) and Y-score (partner→IGHV1OR21-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR8G1 →	+0.119	+5.217	<.001	.007	3	2
SARC	OR56A1 →	+0.116	+5.954	<.001	.002	3	1
SARC	RN7SKP36 →	+0.170	+5.620	<.001	.004	3	1
SARC	SDC4P →	+0.163	+5.224	<.001	.006	3	1
SARC	RFKP1 →	+0.195	+5.620	<.001	.004	3	1
SARC	SLC20A1P1 →	+0.164	+5.005	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

OR8G1 by IGHV1OR21-1 expression — LUAD

Explore this box plot interactively →