IGHV1OR16-4

Across TCGA patient cohorts, IGHV1OR16-4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,221 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV1OR16-4-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and Antibacterial humoral response. Each is linked with IGHV1OR16-4 in more than 25 cancer types. Because this analysis shows association rather than direction, both IGHV1OR16-4-to-partner and partner-to-IGHV1OR16-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHV1OR16-4-low versus IGHV1OR16-4-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1OR16-4→partner) and Y-score (partner→IGHV1OR16-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.110	+0.303	<.001	<.001	3	25
ESCA	Immunoglobulin production →	+0.085	+0.353	<.001	<.001	3	25
LGG	Antibacterial humoral response →	+0.192	+0.016	<.001	.007	1	26
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.152	+0.261	<.001	<.001	3	24
THCA	Complement activation, classical pathway →	+0.180	+0.267	<.001	<.001	3	24
THCA	Antimicrobial humoral response →	+0.114	+0.273	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,221 associations by consensus.

B cell mediated immunity by IGHV1OR16-4 expression — THCA

Explore this box plot interactively →