IGHV1OR16-4

Across TCGA pan-cancer cohorts, IGHV1OR16-4 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGHV1OR16-4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR16-4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1OR16-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, KIRC, and THCA are the cancer types where IGHV1OR16-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.773	0.619	.001	143	view →
KIRC	DFS	Tertile	All	0.496	0.645	.009	60	view →
THCA	DFS	Tertile	All	0.769	0.938	.003	48	view →
CHOL	OS	Tertile	II,III,IV	0.019	0.675	<.001	36	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	27	view →
KIRP	DFS	Tertile	All	0.482	0.819	.004	24	view →
OV	OS	Tertile	III,IV	0.715	0.849	.003	18	view →
PAAD	OS	Tertile	II,III,IV	0.797	0.558	.027	15	view →
READ	DFS	Tertile	IV	1.000	0.484	.031	12	view →
MESO	OS	Tertile	III,IV	0.720	0.490	.015	9	view →
LGG	OS	Tertile	All	0.542	0.892	.008	9	view →
LIHC	OS	Tertile	All	0.945	0.674	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGHV1OR16-4–HNSC (DFS)

Open the HNSC breakdown →